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In this simple example of retrosynthetic analysis, tert-butanol (the target molecule) is envisioned to arise via hydrolysis of 2-bromo-2-methylpropane.
Arizona State University, USA - Format: PDF Retrosynthesis The synthetic route to a target molecule: definitions and terms - Format: PDF Retrosynthesis Tutorial: Advanced Organic Chemistry - Format: PDF Retrosynthesis Lecture notes: designing organic syntheses.
Retrosynthesis or retrosynthetic analysis is a strategy for planning an organic synthesis by disconnecting a target molecule into precursor materials.
This steps are repeated until available starting materials are reached.
Thus, if we form two Br bonds to each of the carbons, we can then form the alkyne from 1,2-dibromo-3,3dimethylbutane.
In the forward reaction, we can do this with a strong base such as sodium ethoxide (Na OEt) in ethanol to form the alkyne. To do this, we would have to carry out an addition reaction.