Proton Research Paper

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This is compared to only three published phase III clinical trials of PBT.

There are still uncertainties around the use of PBT that research needs to answer and we have a way to go before we can use PBT with the same confidence and knowledge base that we have amassed for conventional radiotherapy.

Clinical trials are often complex, multi-centre projects carried out across disparate geographical locations and involving large numbers of patients.

With PBT in the UK, there are added complexities for research – the patient pathway will change for patients who will receive PBT at one of the two PBT centres whereas the standard of care treatment will be delivered locally; we need innovative clinical trial methodology and there is a limit on the research capacity at the PBT centres.

The second planned facility is due to open at University College London Hospital in 2020.

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In this blog post, Professor David Sebag-Montefiore, Chair of NCRI’s Proton Beam Therapy Clinical Trials Strategy Group, tells us why research in to PBT is so important and how the NCRI is developing a collaborative research strategy around PBT for the UK.At an NCRI CTRad workshop in 2018, we reviewed 10 clinical trials proposals involving PBT and provided investigators with expert feedback to strengthen their proposals.At least three of these have progressed further, and we are now supporting the development of these proposals to move them to the next stage; we will also be assisting with the progress of the other proposals.PBT is currently approved for use for treatment in children and for some central nervous system tumours.For treatment of wider patient populations and cancer types, more research is needed to determine if the theoretical rationale for PBT treatment (that it offers benefits over conventional radiotherapy in sparing radiation dose to normal tissue) occurs in practice.Since each element has a unique number of protons, each element has its own unique atomic number.The word proton is Greek for "first", and this name was given to the hydrogen nucleus by Ernest Rutherford in 1920.For further information, including about cookie settings, please read our Cookie Policy .By continuing to use this site, you consent to the use of cookies.One or more protons are present in the nucleus of every atom; they are a necessary part of the nucleus.The number of protons in the nucleus is the defining property of an element, and is referred to as the atomic number (represented by the symbol Z).


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